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Figure 1
Lateral movement (arrow) of β-strands during α1-antitrypsin polymerization and a strategy for blockade via targeting of an allosteric site (ellipse) lateral to β-sheet A (blue). Expansion of the β-sheet to accommodate an extra β-strand derived from the reactive loop (red) fills this site. In this figure, the structure of native α1-antitrypsin (PDB entry 1qlp) is depicted using PyMOL (DeLano, 2002BB4) cartoon settings.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 67| Part 12| December 2011| Pages 1492-1497
https://doi.org/10.1107/S1744309111040267
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