 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 1]](be5207fig1mag.jpg)
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Figure 1
Pim-1 kinase hinge region and P-loop. The overall tertiary structure of Pim-1 kinase is shown on the left in a cartoon format, with each secondary-structure element coloured using a rainbow scheme. The N-terminal lobe is at the top and the α-helical C-terminal lobe is at the bottom. A close-up view of the binding-site region (in the yellow oval) is shown on the right. The hinge region is shown on the left in green. Residues Glu121, Arg122, Pro123, Glu124 and Val126 are depicted as stick models. Ser54, at the end of the P-loop, is also highlighted. The interaction with Glu121 which is usually formed by mimetics is depicted by a dashed line. The P-loop is shown on the right side of the binding site in dark blue. Residues Phe49 and Lys67 are highlighted. The dashed line denotes the common interaction with Lys67. |
![[Figure 1]](be5207fig1.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
