Crystallization and preliminary crystal structure analysis of the ligand-binding domain of PqsR (MvfR), the Pseudomonas quinolone signal (PQS) responsive quorum-sensing transcription factor of Pseudomonas aeruginosa

Xu, N.; Yu, S.; Moniot, S.; Weyand, M.; Blankenfeldt, W.

doi:10.1107/S1744309112032538

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 1
Importance of PqsR in a simplified diagram of the P. aeruginosa quorum-sensing cascade. (1) The PQS system itself is activated by the LasR–N-(3-oxododecanoyl)-L-homoserine lactone (C₁₂-AHL) complex. (2) Binding of PQS to PqsR leads to autoinduction of the pqs operon. (3) PqsE enhances the activation of virulence genes (4) by RhlR–N-butyryl-L-homoserine lactone (C₄-AHL) through an unknown mechanism.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 68| Part 9| August 2012| Pages 1034-1039

doi:10.1107/S1744309112032538

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