Figure 3
(a) Superposition of the α5–α6 helices of the CARD8 (orange), NLRP1 (pink), Apaf-1 (cyan) and procaspase-9 (green) CARDs. The orientation of the α6 helices differ by ∼45° between the CARD8/NLRP1 and Apaf-1/procaspase-9 CARDs. (b) The α5–α6 helices of the CARD8 CARD are shown as ribbons and a portion of the α1 helix is shown as a Cα trace, with the Val529 and Phe453 side chains displayed as spheres. Similar views and equivalent residues are shown for the NLRP1 (pink) (c), Apaf-1 (cyan) (d) and procaspase-9 (green) (e) CARDs. |