view article

Figure 5
Structural alignment of PatF (green) and DMATS (cyan) highlighting the key residues involved in DMATS–DMAPP binding and their absence in PatF. Lys187 of DMATS forms a salt bridge to the phosphate O atom of the DMAPP mimic (2.67 Å), while Asp178 forms a stabilizing interaction with Arg100, which in turn forms a salt bridge to the DMAPP mimic. In PatF, Lys187 and Asp178 correspond to Met136 and His125, respectively. These residue changes would abolish these DMAPP-binding interactions.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Follow Acta Cryst. F
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds