Figure 5
Comparison of E. coli UNG and D4. (a) Stereo diagram showing a superposition of amino-acid residues within 4.5 Å distance of uracil in E. coli UNG (PDB entry 2eug
) and D4. Amino-acid residues are shown as stick models. Color code for D4: N, blue; O, red; C, yellow; E. coli UNG is shown in cyan. (b) Stereo drawing showing superposition of the uracil-specificity motif, catalytic water loop and leucine-intercalation loop in E. coli UNG (PDB entry 2eug
) and the corresponding regions in D4 (subunit B). The active-site histidines His187 of E. coli UNG and His181 of D4 are labeled. Color code for D4: N, blue; O, red; C, green in D4; E. coli UNG is shown in magenta. |