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Figure 11
As shown here, most proteins have certain solubility minima as a function of pH. One can take advantage of this property to produce supersaturation by altering a system from a pH permitting high solubility (P1 or P2) to a point of low solubility (P0). This is a powerful approach to promoting crystallization of macromolecules.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 70| Part 1| December 2014| Pages 2-20
doi:10.1107/S2053230X13033141
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