view article

Figure 1
The suggested catalytic mechanism of endothiapepsin. A water molecule bound to Asp32 and Asp215 nucleophilically attacks the scissile-bond carbonyl. A tetrahedral intermediate is then generated and stabilized by hydrogen bonds. The C—N bond is cleaved by transferring a proton to the amino group. Hydrogen bonds are indicated by dotted lines.

ISSN: 2053-230X
Follow Acta Cryst. F
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds