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Figure 2
p202 HINa recognizes dsDNA in a nonspecific manner. (a) Two loop regions of p202 HINa bind to the major groove of dsDNA. Residues interacting with dsDNA are shown as a cyan mesh. (b, c) Detailed interactions between the II-loop1,2 region (b) and the II-loop4,5 region (c) of p202 HINa and dsDNA. Residues involved in DNA binding are highlighted as cyan sticks and the II-loop1,2 region is also coloured cyan. The water molecules mediating the protein–DNA interaction are shown as red balls. (d) Sequence alignment of mouse p202 HINa (SwissProt entry Q9R002), mouse Aim2 HIN (Q91VJ1), human AIM2 HIN (O14862) and human IFI16 HINb (Q16666). The secondary-structure elements defined in p202 HINa are shown at the top of the alignment. The residues of p202 HINa involved in the interaction with dsDNA are boxed in blue and those of human AIM2 HIN and IFI16 HINb are boxed in red. The solid boxes indicate interactions involving side chains from the HIN domains, and the dotted boxes indicate main-chain interactions.

ISSN: 2053-230X
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