 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 1]](pu5409fig1mag.jpg)
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Figure 1
The forward and reverse transsulfuration pathway in yeast. Transsulfuration is the metabolic pathway that allows the interconversion of cysteine and methionine through the common intermediates homocysteine and cystathionine. In yeast, both forward and reverse routes are present, which enables the use of either cysteine or methionine as a sulfur source. The forward transsulfuration pathway (dotted grey arrows), which is also found in bacteria and plants, catalyzes the formation of methionine from cysteine, while the reverse transsulfuration pathway of mammals (thick black arrows) leads to the formation of cysteine from methionine. Unlike human and other mammalian CBS enzymes, yeast CBS is haem-independent and its activity is not regulated by S-adenosyl-L-methionine (AdoMet). Abbreviations: CBS, cystathionine β-synthase; CBL, cystathionine β-lyase; CGL, cystathionine γ-lyase; CGS, cystathionine γ-synthase. |
![[Figure 1]](pu5409fig1.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
