Figure 2
Co-crystal structures of catPARP1 and catPARP2 in complex with BMN 673. (a) Noncrystallographic symmetry-related molecules superimposed at the conserved pocket residues interacting with BMN 673. (b) Fo − Fc OMIT electron-density map (contoured at 2σ) of BMN 673 at the nicotinamide-binding site. |