Figure 1
Cartoon schematic summarizing patellamide biosynthesis. All of the required biosynthetic machinery is clustered into a single operon. The precursor peptide (PatE) is processed by PatD, generating thiazoline and oxazoline heterocycles, cleaved at the N-terminus by PatA and cleaved at the C-terminus, macrocyclized and oxidized by PatG to form highly modified patellamides. |