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Figure 1
Cartoon schematic summarizing patellamide biosynthesis. All of the required biosynthetic machinery is clustered into a single operon. The precursor peptide (PatE) is processed by PatD, generating thiazoline and oxazoline heterocycles, cleaved at the N-terminus by PatA and cleaved at the C-terminus, macrocyclized and oxidized by PatG to form highly modified patellamides.

ISSN: 2053-230X
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