 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 4]](nj5222fig4mag.jpg)
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Figure 4
(a) Crystal structure of tCid1 (PDB entry 4e7x) highlighting the domain architecture, with the N-terminal domain (NTD) rendered in blue, the C-terminal domain (CTD) rendered in green and the β-trap door (β-TD) feature of the structure which helps in substrate containment (Yates et al., 2012  , 2015) rendered in red. The sites that are mutated in our tCid1 RNA-binding mutant are shown as side chains (spheres) and are rendered in orange. (b) The crystal packing of PDB entry 4e7x showing the location of Lys133, Arg137, Arg277 and Lys282 and how this relates to crystal packing. This crystal structure possesses four molecules per asymmetric unit, which are rendered in green (chain A), cyan (chain B), purple (chain C) and yellow (chain D). In all chains the positions of Lys133, Arg137, Arg277 and Lys282 are rendered in orange and are shown as side chains (spheres). (c, d) The crystal packing of the RNA-binding mutant crystal structures in space groups P1 (c) and P21 (d). The positions of K133A/R137A/R277A/K282A are highlighted in orange. Both crystal forms possess two molecules per asymmetric unit, which are rendered in green (chain A) and cyan (chain B) in both cases. This figure was generated using PyMOL (Schrödinger). |
![[Figure 4]](nj5222fig4.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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