Structure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase

Nakamura, A.; Tamura, N.; Yasutake, Y.

doi:10.1107/S2053230X15017896

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 2
Comparison of HIV-1 RT structures crystallized in different space groups. HIV-1 RT structures were aligned by the residues of p51 using Chimera (Pettersen et al., 2004

). The displacement values of the residues of the p66 subunit between HIV-1 RT Q151M and six HIV-1 RT representatives were calculated using Chimera. The colours used to indicate HIV-1 RT Q151M are the same as those used in Fig. 1

. Other HIV-1 RT structures are coloured black (p66) and grey (p51). The colours in the graphs correspond to the colours of p66. (a) PDB entry 1rth , P2₁2₁2₁; (b) PDB entry 3hvt , C2; (c) PDB entry 2rf2 , C222₁; (d) PDB entry 1dlo , C2; (e) PDB entry 3ith , P2₁; (f) PDB entry 3v4i , bound to DNA, P2₁.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 71| Part 11| October 2015| Pages 1384-1390

doi:10.1107/S2053230X15017896

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