view article
Figure 7
Occupation of the selectivity pocket of Sirt2 with large hydrophobic moieties such as EX243 or the DMP group of SirReal2 induces a conformational shift of the hinge loop and consequently significantly enlarges the selectivity pocket, which leads to an isotype-selective inhibition of Sirt2. Exploiting this binding pocket and the flexibility of the hinge loop of Sirt2 with large hydrophobic moieties presents a potential strategy for the development of Sirt2-selective inhibitors.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 71| Part 12| December 2015| Pages 1498-1510
https://doi.org/10.1107/S2053230X15019986
Follow Acta Cryst. F
Sign up for e-alerts
E-alerts
Follow Acta Cryst. on Twitter
Twitter
Follow us on facebook
Facebook
Sign up for RSS feeds
RSS