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Figure 1
Factors influencing protein stability. (a) Protein compositional stability and conformational stability as key determining factors for successful crystallization. The stability properties of the protein determine whether the process of crystal formation is possible. Thermodynamics establish the necessary conditions for crystallization, and the kinetics and dynamics of the processes determine whether a possible scenario actually becomes reality. Only if all of the parameters are satisfied will crystal formation proceed. Figure adapted from Rupp (2015BB193). (b) The marginal net stability of a folded protein is highlighted with respect to the contributing factors; the overwhelming lack of conformational stability is only marginally balanced by the contribution of van der Waals (VdW), hydrogen-bonding (H-bonds) and hydrophobic forces. Figure adapted from .

ISSN: 2053-230X
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