Figure 2
Matrix of examples of protein stability and disorder. (a) Examples of proteins with high conformational stability include the protein–protein destabilizing compound cyclosporin in complex with calcineurin and cyclophilin (Huai et al., 2002) and (b) the protein–protein stabilizing drug Tafamidis in combination with transthyretin (Bulawa et al., 2012). (c) Examples of proteins with low conformational stability include the serpins, which undergo large changes in fold and oligomerization state (Yamasaki et al., 2008), and (d) intrinsically disordered proteins (IDPs) such as the tumor suppressor protein p53 (Mujtaba et al., 2004). |