Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe–2S] cluster

Abdalla, M.; Dai, Y.-N.; Chi, C.-B.; Cheng, W.; Cao, D.-D.; Zhou, K.; Ali, W.; Chen, Y.; Zhou, C.-Z.

doi:10.1107/S2053230X16013418

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 2
Crystal structure of yeast Grx6C bound to GSH and a [2Fe–2S] cluster. (a) The dimeric structure. Subunits A and B are coloured cyan and magenta, respectively. Secondary structures are labelled in subunit A. Two GSH molecules and the bridged [2Fe–2S] cluster are shown as sticks. S atoms are coloured yellow and Fe atoms brown. (b) Comparison of the overall structure between subunit A (cyan) of holo Grx6C and GSH–Grx6C (light magenta). (c) σ_A-weighted 2F_o − F_c density map of Cys136 and the GSH-linked [2Fe–2S]. (d) Stereo representation of the [2Fe–2S] cluster coordination and GSH–Grx6C interactions. Two GSH molecules and the bridged [2Fe–2S] cluster are shown as bold sticks. Residues involved in GSH interaction are shown as sticks. Polar interactions are indicated by dashed lines.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 72| Part 10| October 2016| Pages 732-737

https://doi.org/10.1107/S2053230X16013418

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