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Figure 3
Comparison of structures of ISC-ligated Grxs. (a) Superposition of holo Grx6C (cyan) with human Grx2 (pink) and human Grx5 (yellow). (b) Multiple sequence alignment of solved structures of ISC-ligated Grxs. The active-site Cys136 and residues involved in GSH and [2Fe–2S] stabilization are indicated with a red star and blue triangles, respectively. The multiple sequence alignment was performed using ESPript (https://espript.ibcp.fr/ESPript/cgi-bin/ESPript.cgi). The sequences are Saccharomyces cerevisiae Grx6C (ScGrx6C), Homo sapiens Grx2 (HsGrx2), Populus tremula × Populus tremuloides GrxC1 (PtGrxC1), Arabidopsis thaliana GrxC5 (AtGrxC5), Homo sapiens Grx5 (HsGrx5) and Escherichia coli Grx4 (EcGrx4).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 72| Part 10| October 2016| Pages 732-737
https://doi.org/10.1107/S2053230X16013418
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