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Figure 4
Substitutions of the phenylalanine at position 3, shown in stereo and superimposed on the cQFD meditope (green C atoms). (a) Substitution of phenylalanine with glutamine led to multiple side-chain rotamers (hot pink C atoms). (b) Substitution of phenylalanine with histidine led to a single conformation exposed to the solvent (cyan C atoms). (c) Based on these observations, we substituted phenylalanine with diphenylalanine (orange C atoms). One phenyl group of the diphenylalanine substitution superposed with the phenyl ring of the cQFD meditope. The other phenyl group superposed well with the imidazole ring of the histidine meditope variant.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 72| Part 11| November 2016| Pages 820-830
https://doi.org/10.1107/S2053230X16016149
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