view article

Figure 4
Substitutions of the phenylalanine at position 3, shown in stereo and superimposed on the cQFD meditope (green C atoms). (a) Substitution of phenylalanine with glutamine led to multiple side-chain rotamers (hot pink C atoms). (b) Substitution of phenylalanine with histidine led to a single conformation exposed to the solvent (cyan C atoms). (c) Based on these observations, we substituted phenylalanine with diphenylalanine (orange C atoms). One phenyl group of the diphenylalanine substitution superposed with the phenyl ring of the cQFD meditope. The other phenyl group superposed well with the imidazole ring of the histidine meditope variant.

ISSN: 2053-230X
Follow Acta Cryst. F
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds