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Figure 7
Substitutions of leucine at position 10, shown in stereo and superimposed on the cQFD meditope. Leu10 packs against a shallow hydrophobic pocket. Glutamine was substituted for Leu10 in an effort to form a hydrogen bond to the hydroxyl group of Tyr87 adjacent to the hydrophobic pocket. The cyan spheres represent two water molecules present in the apo structure (PDB entry 1yy8).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 72| Part 11| November 2016| Pages 820-830
https://doi.org/10.1107/S2053230X16016149
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