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Figure 7
Substitutions of leucine at position 10, shown in stereo and superimposed on the cQFD meditope. Leu10 packs against a shallow hydrophobic pocket. Glutamine was substituted for Leu10 in an effort to form a hydrogen bond to the hydroxyl group of Tyr87 adjacent to the hydrophobic pocket. The cyan spheres represent two water molecules present in the apo structure (PDB entry 1yy8).

ISSN: 2053-230X
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