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Figure 8
Half-lives of meditope variant–cetuximab interactions. While the on-rate of a bimolecular interaction is dependent on concentration, the off-rate is not. The half-life is related to the off-rate through t = ln(2)/kd. The dashed line represents the lower limit on the determination of kd (0.5 s−1, corresponding to a 1.4 s half-life.) Note that several of the variants were cyclized through a diglycine linker, of which GQ(2-Br-F)DLSTRRLKG [F3(2-BrF)] and GQ(4-Br-F)DLSTRRLKG [F3(4-BrF)] allowed the determination of kinetic constants.

ISSN: 2053-230X
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