Figure 5
Surface-charge diagrams of (a) ERG10, (b) T2 and (c) bCT. Electrostatic surface potential diagrams were drawn in an identical orientation after superposition. The covering loops are shown as green, cyan and red stick models, respectively. His192 of T2, His156 of bCT and the corresponding Ala159 of ERG10 at the entrance to the pantetheine-binding tunnel are labelled. The negative potential of the covering loop, which is highlighted with a dotted ellipse, in ERG10 differs from the surface potential in T2 and bCT. The corresponding residues Glu156 (ERG10), Asn189 (T2) and Tyr153 (bCT) are also labelled. |