Crystal structure of cytoplasmic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae

Zhou, P.; Zhu, Z.; Hidayatullah Khan, M.; Zheng, P.; Teng, M.; Niu, L

doi:10.1107/S2053230X17016971

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 8
Comparison of structural superpositions of molecule A (red or blue cartoon model) onto molecule B (green or purple cartoon model) of (a) ERG10 and (c) the Cys91Ala mutant. Polypeptide-chain movements occur at the N-terminus and C-terminus of the disordered region only in molecule A of ERG10, as indicated by the black and blue ellipses, respectively. The two corresponding regions in the Cys91Ala mutant with identical conformation are also indicated by black and blue ellipses, respectively. (b) A CoA molecule was docked into molecule A of ERG10 (red cartoon model) by superposing it on molecule A of T2 (cyan cartoon model; PDB entry 2ibu) in complex with a CoA molecule. His228 and Ser252 of molecule A of ERG10, which clash significantly with the docked CoA molecule, are highlighted with black circles.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 74| Part 1| January 2018| Pages 6-13

https://doi.org/10.1107/S2053230X17016971

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