 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 1]](ir5002fig1mag.jpg)
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Figure 1
Importance of Notch fucosylation for ligand interaction. (a) Surface and cartoon representations of the Notch1–DLL4 complex (PDB entry 4xl1; Luca et al., 2015  ). Notch1 EGFs 11–13 are shown in green and the MNNL-DSL-EGF1 Delta domains are shown in pink. The fucose (orange) modification of Notch1 Thr466 and its interactions with DLL4 residues are depicted in the left panel. (b) Surface and cartoon representation of the Notch1–Jagged1 complex (PDB entry 5uk5; Luca et al., 2017). Notch 1 EGFs 8–12 are shown in green, the C2-DSL-EGF1–3 Jagged domains are shown in red and Notch fucose is shown in orange. The interactions of the Notch1 fucose modifications of Thr466 and Thr311 are depicted in the upper and lower panels, respectively. Ca2+ ions are shown as green spheres. |
![[Figure 1]](ir5002fig1.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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