 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 1]](rl5165fig1mag.jpg)
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Figure 1
Geometric reference frame for Fc conformational analysis. (a) shows the least-squares dyad relating the tightly associated and structurally conserved CH3 domains. The centroids of the four domains are shown as spheres. Using this dyad as a vertical axis and the CH3 domain centroids to define the horizontal axes of a Cartesian frame, CH2 loci in different structures can be compared (after superposing their CH3 domains). (b) shows a superposition of seven Fc structures from the orthorhombic crystal form, showing that the CH2 domains have a wide range of positional variation. The star indicates the Asn residue to which the glycans attach. This point varies by up to 1.2 nm among the structures, suggesting that the glycans explore a large conformational space. (c) shows the same data using the proposed reference frame, and includes two additional Fc structures: the complexes with PDB codes 3sgj and 5u66. |
![[Figure 1]](rl5165fig1.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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