Figure 1
Conformations of the MBP-DUSP1 CD–DARPin complexes. The MBP, DUSP1 CD and DARPin moieties are depicted in green, cyan and magenta, respectively, in (a)–(c). MBP has the same orientation in all panels. (a) The DARPin 16 complex in the absence of bound maltose. (b) The DARPin 16 complex with bound maltose. Maltose is shown as red spheres. (c) The off7 complex. (d) Structural alignment of the two DARPin 16 complexes with (green) and without (red) maltose. (e) Crystal packing of DARPin 16 complexes with (green) and without (red) maltose. |