Figure 3
The overall crystal structure of N-acetylneuraminate lyase from F. nucleatum. (a) Cartoon representation of FnNanA with individually coloured secondary structures. Secondary-structure elements are labelled sequentially (with lower case letters corresponding to β-strands and upper case letters corresponding to α-helices). The Lys161–pyruvate Schiff base intermediate in the active site is displayed as sticks with yellow C atoms. (b) The tertiary structure (tetramer) of FnNanA with each subunit shown in cartoon presentation in a different colour. The figures were generated using the PyMOL molecular-graphics system (DeLano, 2002). |