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Figure 4
Electron-density map of the Schiff base formed by Lys161 with pyruvate. Complex showing the interaction of the pyruvate enamine with the enzyme. The pyruvate is covalently linked to Lys161 and makes hydrogen bonds to Ser44 and Thr45. The hydrogen-bonding network to Tyr133 and a conserved water molecule are also shown. The electron density represented by the grey mesh was contoured at the 1σ level, showing continuous density linking the C2 atom of pyruvate and the N atom of Lys161. This figure was generated using the PyMOL molecular-graphics system (DeLano, 2002BB8).

ISSN: 2053-230X
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