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Figure 3
Assessment of an ensemble of conformations from the PDB. (a) An ensemble generated from 84 different actin structures (taken from the PDB) is shown (in light blue) within an actin monomer density map [segmented from an 8.9 Å resolution actin filament (EMD code 1990; Behrmann et al., 2012BB7), in grey]. (b) The cluster dendrogram of the fits is shown alongside, with the colour bars representing the CCC score of each fit (from white to blue, low to high score). Each cluster is coloured differently. (c) The top 10% scoring fits of the actin monomer from (a), selected on the basis of the CCC and MI ranking (data not shown), are shown (in dark blue) within an actin monomer density map [as in (a)]. The subdomains 1–4 (D1, D2, D3 and D4, respectively) and the DNase-I loop are labelled.

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