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![[Figure 2]](aj5252fig2mag.jpg)
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Figure 2
Linear and logistic regression fits for query residues valine (V) and aspartate (D) from the 18-protein transient-binding subset. Here, the least-squares fit corresponds to the NACCESS RSA values regressed on E6 and amino acid type (AA). For illustrative purposes only two amino acid types are shown. Valine (top) and aspartate (bottom) include 177 and 172 residues, respectively. Both least-squares fits have a slope (E6) of 10.56, but they have different corresponding intercepts 13.83 and 45.17. The residues correctly classified by the logistic model (E6+AA) are shown in red (127 for V, 148 for D). Note, 76.49 (linear) and 75.64% (logistic) of all 2786 residues are classified correctly. Here, a 20% threshold was utilized in both observed and predicted RSA values to create classifications. Moreover, the results were validated by evaluating the fitted model on a 13-protein subset (2049 residues) of the Manesh-215 test set consisting of transient-binding proteins (Pettit et al., 2007  ). Here we observe slightly higher accuracies of 76.34 (linear) and 77.27% (logistic). |
![[Figure 2]](aj5252fig2.jpg)
 | JOURNAL OF APPLIED CRYSTALLOGRAPHY |
ISSN: 1600-5767
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