The results of the `Find best region' pairwise P-value analysis in Baseline mode for the lysozyme data of Fig. S3 in the supporting information. The start and end frames were 1160 and 1310, with a 20-frame sliding window size. (Top panel) With one-every-second q-value sampling and no Holm–Bonferroni adjustment. (Bottom panel) Without sampling and with the Holm–Bonferroni adjustment. In both panels, the red cluster-size histogram window is enlarged to show the data relevant for the baseline definition.