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Figure 5
Final molecular modelling results for human IgA1 antibody (Hui et al., 2015BB23). The protein main chain is shown as a yellow ribbon. The structure was taken from the median of the 112 models in the best-fit cluster. The O-glycans at Thr225, Thr228 and Ser232 in the hinge and the N-glycans at Asn263 and Asn459 in the Fc region and tailpiece, respectively, are shown as green sticks. (a) View face on to the Fc region in the best-fit Y-shaped IgA1 structure. The two FcαR sites on the Fc region are shown occupied by two FcαR receptors (blue: PDB code 1ow0; Herr et al., 2003BB73). (b) View edge on to the Fc region in this best-fit IgA1 structure. This view was rotated by 90° about a vertical axis, and the two blue FcαR receptors were deleted. This view shows the location of the O-glycans and N-glycans in IgA1 as green sticks.

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