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Figure 4
SREFLEX, flexible refinement of high-resolution models based on SAXS and normal mode analysis. Vectors show the conformational change modelled for hepatitis C virus NS3 helicase by SREFLEX when starting from PDB code 8ohm (Cho et al., 1998BB66) (unbound conformation, blue) guided by the SAXS profile of a nucleotide-bound conformation (dots, simulated from PDB code 3kqn; Gu & Rice, 2010BB67).

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