Figure 2
Principle of the method of crystallization with temperature changes at a constant concentration of crystallizing agent. Kinetic pathways schematizing the standard kinetic trajectory A1, resulting in the induction of nucleation in the zone of the spontaneous nucleation and respective crystal growth in the metastable zone due to the controlled temperature variations (a), and other alternative workflows A2, showing additional temperature variations covering the stages of arrival at equilibrium in workflow A1 (b), and induction of the crystal growth of seeded crystals in the metastable zone as a result of the controlled temperature variations (c), supplemented by additional temperature variations covering the stages of arrival at equilibrium (d). |