Figure 3
Principle of the method of crystallization at constant temperature with variations in concentration of crystallization agent. Kinetic pathways schematizing the standard kinetic trajectory B1, resulting in the induction of nucleation in the zone of spontaneous nucleation and respective crystal growth in the metastable zone due to the controlled variations of the precipitant concentration (a), and other alternative workflows B2, showing additional precipitant concentration variations covering the stages of arrival at equilibrium in workflow B1 (b), and induction of the crystal growth of seeded crystals in the metastable zone as a result of the controlled precipitant concentration variations (c), supplemented by additional precipitant concentration variations covering the stages of arrival at equilibrium (d). |