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![[Figure 7]](ge5081fig7mag.jpg)
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Figure 7
NMATOR models conformational changes in RNA structures to fit SAS data, while preserving bond lengths. Both the initial and target models were obtained from the solution NMR ensemble of U65 Box H/ACA snoRNA (35 nt; PDB ID 2pcv; Jin et al., 2007  ). The target model is shown as grey spheres in the bottom-left inset, with the initial model superimposed in cyan. SAXS data were simulated from the target model with IMSIM. The conformational differences between the initial and target models are detected as a poor fit between the IMSIM-simulated SAXS data from the target and the scattering data computed by CRYSOL from the initial model (statistics are summarized in Table 1). The NMATOR model (red) recapitulated the unbending of the short helix, resulting in a better correspondence to the target model and a much better fit to the simulated data. The residuals are shown in the bottom panel. |
![[Figure 7]](ge5081fig7.jpg)
 | JOURNAL OF APPLIED CRYSTALLOGRAPHY |
ISSN: 1600-5767
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