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![[Figure 4]](te5077fig4mag.jpg)
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Figure 4
(a) Illustration of the compound-screening workflow. Compound molecules were dissolved in DMSO and introduced into the channel by capillary action. The solvent was then allowed to evaporate at room temperature, leaving the compounds coated onto the inner surface of the channel. Finally, a slurry of crystals was introduced into the coated channel by capillary action. Crystals were prevented from passing out of the channel by notches at the outlet end (see inset). The inlets and outlets were then sealed with epoxy. (b) Optical micrograph of a channel in a fabricated chip, showing feature details. The channel was filled with red food coloring for visualization. The scale bar represents 1 mm. (c) A top view of a fabricated device with all channels filled with red food coloring. The chip was inserted into a 3D-printed frame, which was mounted on a magnetic base. (d) A photograph showing the automated sample filling process performed by a mosquito liquid-handling robot. The chip-inserted frame (on the right side) was placed in a 3D-printed cassette having the same size as a standard well plate. The robot was programmed for automated and precise dispensing of solution (red food coloring shown as an example) onto the channel inlets where capillary action was then used to fill the channel. |
![[Figure 4]](te5077fig4.jpg)
 | JOURNAL OF APPLIED CRYSTALLOGRAPHY |
ISSN: 1600-5767
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