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Figure 5
(a) Photograph of a device in a 3D-printed frame, mounted on the goniometer via a magnetic base at the IMCA-CAT beamline 17-ID at the APS. (b) A heat map obtained from X-ray rastering, showing potential crystal locations. Each square represents a raster area and a deeper red (or higher score) indicates a higher pixel intensity and thus a better chance for finding a strongly diffracting crystal. (c) A high-resolution Fo–Fc electron density map of Gal-3 crystals with TD139 bound based on a crystal identified via raster scanning, along with the molecular structure of the compound. (d) An illustration of the procedure for automated sample alignment and raster scanning at SSRL beamlines. A raster grid is overlaid onto the channels after placing anchors at the channel ends to define feature positions. The left photograph shows a channel outline recognized by the software and the right photograph shows the rastering progress. (e) Software view of trypsin crystals identified after the raster process with the beam focus targeted onto the crystal. (f) An example diffraction pattern from the crystal.

Journal logoJOURNAL OF
APPLIED
CRYSTALLOGRAPHY
ISSN: 1600-5767
Volume 54| Part 4| August 2021| Pages 1034-1046
https://doi.org/10.1107/S1600576721004155
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