Figure 3
(a) SWAXS data of the PEGylated HSPC liposomes with cholesterol added. (b) Corresponding neat HPSC liposomes without cholesterol. The SAXS data are fitted using a five-layer core–multishell model (dash–dotted curves) with core radii of (c) 530 Å and (d) 428 Å and a multilayer model with five Gaussian electron density profiles (solid curves). In (c) and (d), the units of relative electron density Δρ (with respect to the water solvent) are used in the Gaussian interface model, with zero representing the absolute electron density of water (0.334 e− Å−3). (e) Cartoon of the local structure of the PEGylated HSPC liposome, with z = 0 for the center of the bilayer. PtP represents the lipid head-to-head distance of the bilayer. The thin arrows in the WAXS region of (a) and (b) indicate the characteristic 2D hexagonal packing of the bilayer lipids of the liposomes. |