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Figure 11
cAMP-dependent protein kinase A in (a) the unbound form (1j3h), (b) bound to cAMP (2cpk), and (c) bound to cAMP and ATP (1atp). Students might notice that the top part of the protein curls in to bind the ligands. They might zoom in to the ATP in panel 3 and notice it has interactions with ions in the protein, which is a stabilizing interaction that is important to the mechanism.

Journal logoJOURNAL OF
APPLIED
CRYSTALLOGRAPHY
ISSN: 1600-5767
Volume 56| Part 5| October 2023| Pages 1557-1568
https://doi.org/10.1107/S1600576723006805
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