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Figure 2
Quality of the electron-density maps. (a)–(d) 2mFo − DFc electron-density maps (blue mesh) contoured at the 1.5σ level showing close-up views of AR3dark-adapted (PDB entry 6guy, light pink), AR3110 ns (PDB entry 7zy3, light magenta), and the hA2AR binding site in complex with theophylline (PDB entry 8a2o, yellow) and LUAA47070 (PDB entry 8a2p, green), respectively. (e)–(h) mFo − DFc omit electron-density maps contoured at the ±3.0σ level showing strong positive density (green mesh) when ligands are omitted during refinement. Protein residues and ligands are shown as sticks and water molecules as red spheres. Dashed lines in panels (a) and (b) represent the hydrogen-bond network.

Journal logoJOURNAL OF
APPLIED
CRYSTALLOGRAPHY
ISSN: 1600-5767
Volume 56| Part 5| October 2023| Pages 1361-1370
https://doi.org/10.1107/S1600576723006428
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