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Figure 4
Electron-density maps of hA2AR's four di­sulfide bridges (Cys71–Cys159, Cys74–Cys146, Cys77–Cys166 and Cys259–Cys262). (a) and (c) show the 2mFo − DFc (blue mesh, contoured at 1.5σ) and mFo − Fc (green and red meshes, contoured at ±3σ) electron-density maps around the hA2AR four di­sulfide bonds in complex with theophylline and LUAA47070, respectively. (b) and (d) show the omit 2mFo − DFc (blue mesh, contoured at 1.5σ) and mFo − DFc (green and red meshes, contoured at ±3σ) electron-density maps when the di­sulfide bridges are omitted/broken. Here, strong positive electron density is seen where original di­sulfide bridges were formed. The hA2AR residues in complex with theophylline and LUAA47070 are represented by yellow and green sticks, respectively. Pictures were prepared in PyMOL.

Journal logoJOURNAL OF
APPLIED
CRYSTALLOGRAPHY
ISSN: 1600-5767
Volume 56| Part 5| October 2023| Pages 1361-1370
https://doi.org/10.1107/S1600576723006428
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