Figure 2
Isomorphous difference density maps for five halogenated BCL6 ligands at five dose points. The DWD is equal to n multiplied by the dose per dataset. Carbon atoms are shown in yellow, nitrogen atoms in blue, oxygen atoms in red, chlorine atoms in green, bromine atoms in maroon and fluorine atoms in light blue. The following five compounds are shown here: (1) contoured at 0.471 e Å−3 (5σ in Fo15 − Fo1 map), DWD = n × 1.51 MGy; (2) contoured at 0.356 e Å−3 (5σ in Fo15 − Fo1 map), DWD = n × 1.25 MGy; (3) contoured at 0.407 e Å−3 (5σ in Fo15 − Fo1 map), DWD = n × 1.45 MGy; (4) contoured at 0.273 e Å−3 (5σ in Fo15 − Fo1 map), DWD = n × 1.40 MGy; (5) contoured at 0.543 e Å−3 (5σ in Fo15 − Fo1 map), DWD = n × 1.29 MGy. The full 15 dataset dose series of all BCL6 inhibitors is shown in Fig. S3. |