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Figure 4
Neutron reflectometry analysis of d-DMPC bilayers, demonstrating organic solvent detection capabilities and reproducibility assessment. (Top row) Reflectivity profiles for (a) multiple VF replicates, and SALB formations using (b) EtOH and (c) IPA as solvents, with experimental data and MixedSlab model fits. (Bottom row) SLD profiles, showing detailed bilayer architectures with enhanced contrast from deuterated lipids. The profiles reveal the structural consistency between the VF and SALB methods, while enabling quantitative detection of organic solvent incorporation through modified SLD distributions in SALBs. Replicate measurements demonstrate the systematic variability in SALBs. The other two replicates for VF are given in Fig. S1. Both the EtOH-based measurement and the IPA-based SALB measurement 2 were performed at 25°C, the rest at 37°C. The solvent exchange was performed with ultrapure water.

Journal logoJOURNAL OF
APPLIED
CRYSTALLOGRAPHY
ISSN: 1600-5767
Volume 59| Part 2| April 2026| Pages 343-356
https://doi.org/10.1107/S1600576726000312
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