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Figure 6
Scanning SWAXS data of bone biopsies. (a–b) Pathological femoral head core biopsy (dwarfism-affected sample). (a) Macroscopic view of the specimen mounted on the sample holder together with the corresponding optical micrograph showing the scanned area; below, the averaged 2D SAXS pattern over the entire scanned region, the composite SAXS map illustrating the spatial distribution of the scattering intensity across a 1 mm scale, and the resulting orientation map of the collagen nanocrystals are shown. (b) Sub-molecular analysis of the mineral phase: averaged 2D WAXS pattern over the scanned area displaying the characteristic diffraction rings of HAp. The degree of orientation and orientation maps of the 002 HAp reflection highlight the local mineral organization. The 1D integrated WAXS profile (experimental data in black) is shown with the corresponding Rietveld refinement fit (calculated model in red, difference plot in blue), where the 002 peak is specifically marked. The crystal structure of HAp (O = red, Ca = blue, P = black) and a table summarizing the refined unit cell parameters and cell volume are also provided. (c–d) Healthy femoral head biopsy: the same set of analyses is shown, including averaged SAXS and WAXS patterns over the scanned region, SAXS composite map, SWAXS-derived orientation maps and 1D WAXS profile with Rietveld refinement, as described above. White scale bars correspond to 1 mm.

Journal logoJOURNAL OF
APPLIED
CRYSTALLOGRAPHY
ISSN: 1600-5767
Volume 59| Part 5| October 2026|
https://doi.org/10.1107/S1600576726007132