Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

Brannigan, J.A.; Roberts, S.M.; Bell, A.S.; Hutton, J.A.; Hodgkinson, M.R.; Tate, E.W.; Leatherbarrow, R.J.; Smith, D.F.; Wilkinson, A.J.

doi:10.1107/S2052252514013001

Figure 3
Binding of ligands and MyrCoA cofactor. Molecules are in cylinder representation in all panels. The atoms are coloured by element (oxygen, red; nitrogen, blue; sulfur, yellow; phosphorus, magenta; fluorine, silver; chlorine, mauve) with the C atoms coloured by inhibitor: (a) 6KV, grey; (b) 7AH, coral; (c) A6K, green; (d) CWZ, pink; (e) 646 (PDB entry 2wsa ), ice blue. In (f) the MyrCoA and the inhibitors in (a)–(d) are overlaid. (g, h) Two views of the inhibitor ligands overlaid. For clarity, only the proximal 6KV molecule is shown in the overlaps.

IUCrJ

Volume 1| Part 4| June 2014| Pages 250-260

ISSN: 2052-2525

doi:10.1107/S2052252514013001

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