**Figure 6**
(*a*), (*b*) Protein concentration as a function of distance from a simulation of nucleation and growth in one dimension. The concentration is dimensionless. The red dotted line indicates the initial concentration with a supersaturation of 83.3 at *t* = 0. The sites with concentrations that exceed the red line are in the crystalline phase, while those below are in solution. (*a*) Concentration profile at *t* = 250. Slow nucleation rate of *R* = 1 in dimensionless units. (*b*) Concentration profile at *t* = 50. Fast nucleation rate of *R* = 27. (*c*) The average number of crystals per drop as a function of time, , for two nucleation rates obtained from simulation and fitted to equation (3), . The conditions are the same as in (*a*) and (*b*). (*d*), (*e*) Fitting parameters to equation (3) as a function of drop size for two nucleation rates, *R* = 27 and *R* = 1. Arrows indicate the size of the depletion zone. (*d*) The solid lines are the simulated final number of crystals per drop, . The dashed lines are equation (7), . (*e*) The solid lines are the simulated rate of crystal formation, *k*. The dashed lines are equation (8), *k* = *J**V*. (*f*) Conceptual schematic. A drop of volume *V* can be thought of as smaller independent drops of volume |