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Figure 4
Structural characterization of TET family. Cartoon representation of (a) Naegleria TET1–DNA–NOG–Mn2+ complex (PDB code: 4lt5 ) and (b) human TET2–DNA–NOG–Fe2+ complex (PDB code: 4nm6 ), respectively. NOG is shown in sticks with carbon in magenta. Cofactor Mn2+ or Fe2+ is shown as cyan spheres. Three zinc atoms are shown as green spheres. Catalytic substrate 5mC is labeled. Close-up view of the coordination of the cosubstrate NOG, cofactor Mn2+/Fe2+ and catalytic substrate 5mC in the active sites of (c) NgTet1 and (d) human TET2. The hydrogen bonds are displayed as dashed lines and the distance between Mn2+/Fe2+ with 5mC is labeled.

IUCrJ
Volume 1| Part 6| October 2014| Pages 540-549
ISSN: 2052-2525
doi:10.1107/S2052252514020922