Figure 1
SNARE proteins involved in membrane fusion. (a) Domain arrangements of the SNARE proteins: syntaxin, SNAP23/25 and VAMP2 (TMD, transmembrane domain); (b) trans-SNARE-complex formation through interaction of SNARE motifs on t-SNARE proteins (syntaxin and SNAP on the target membrane) with the SNARE motif of the v-SNARE protein (VAMP2) on the vesicle membrane; (c) cis-SNARE complex with the TMD of syntaxin and VAMP2 on the same membrane. The blue circle labeled `N' is the N-peptide. Palmitoylation anchors for SNAP23/25 are not shown in panels (b) and (c). |